$525.00

Elisa kit for the detection of human IL-6 in serum samples

Human Interleukin 6 (IL-6) is a 184 A.A. polypeptide with potential O and N-glycosylation sites, and a significant homology with G-CSF. It is produced by various cells, including T- and B-cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells, astrocytes, bone marrow stroma cells and several tumor cells. It regulates the growth and differentiation of various cell types with major activities on the immune system, hematopoïesis, and inflammation. These multiple actions are integrated within a complex cytokine network, where several cytokines induce (IL-1, TNF, PDGF, IFNs,...) or are induced by IL-6 and the final effects result from either synergistic or antagonistic activities between IL-6 and the other cytokines (IL-1, IL-2, IL-4, IL-5,IFNγ, IL-3, GM-CSF, M-CSF,CSF,...). IL-6 induces final maturation of B-cells into antibody producing cells and is a potent growth factor for myeloma/plasmacytoma cells. It (co-) stimulates T-cell growth and cytotoxic T-cell differentiation. It promotes megakaryocyte development and synergizes with other cytokines to stimulate multipotent hematopoïetic progenitors. It can also induce differentiation and growth inhibition of some leukemia -or non hematopoïetic tumoral cell lines. IL-6 is also a major inducer of the acute phase reactions in response to inflammation or tissue injury. Along with IL-1 and TNF, it induces the synthesis of acute phase proteins (APP) by hepatocytes, each cytokine or combination of cytokines showing a preferential pattern of APP production. IL-6 also interacts with the neuroendocrine system, e.g. by inducing ACTH production. Thus, IL-6 is a pleiotropic cytokine with multiple endocrine, paracrine and possibly autocrine activities in various tissues

 

 

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Catalog #: IL E-3200
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Elisa kit for the detection of human IL-6 in serum samples

Human Interleukin 6 (IL-6) is a 184 A.A. polypeptide with potential O and N-glycosylation sites, and a significant homology with G-CSF. It is produced by various cells, including T- and B-cells, monocytes, fibroblasts, keratinocytes, endothelial cells, mesangial cells, astrocytes, bone marrow stroma cells and several tumor cells. It regulates the growth and differentiation of various cell types with major activities on the immune system, hematopoïesis, and inflammation. These multiple actions are integrated within a complex cytokine network, where several cytokines induce (IL-1, TNF, PDGF, IFNs,...) or are induced by IL-6 and the final effects result from either synergistic or antagonistic activities between IL-6 and the other cytokines (IL-1, IL-2, IL-4, IL-5,IFNγ, IL-3, GM-CSF, M-CSF,CSF,...). IL-6 induces final maturation of B-cells into antibody producing cells and is a potent growth factor for myeloma/plasmacytoma cells. It (co-) stimulates T-cell growth and cytotoxic T-cell differentiation. It promotes megakaryocyte development and synergizes with other cytokines to stimulate multipotent hematopoïetic progenitors. It can also induce differentiation and growth inhibition of some leukemia -or non hematopoïetic tumoral cell lines. IL-6 is also a major inducer of the acute phase reactions in response to inflammation or tissue injury. Along with IL-1 and TNF, it induces the synthesis of acute phase proteins (APP) by hepatocytes, each cytokine or combination of cytokines showing a preferential pattern of APP production. IL-6 also interacts with the neuroendocrine system, e.g. by inducing ACTH production. Thus, IL-6 is a pleiotropic cytokine with multiple endocrine, paracrine and possibly autocrine activities in various tissues

 

 

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SKU: IL E-3200
Width: 8.00
Height: 6.00
Depth: 8.00